Senior Research Associate/Research Scientist I, Translational Biology
C4 Therapeutics Inc Cambridge, MA

We are seeking an enthusiastic, scientifically motivated Senior Research Associate/Research Scientist I with 5+ years of oncology research experience to join our translational biology group. Serving as the technical expert, this candidate will have the opportunity to work on multiple drug targets and play an instrumental role in bringing novel agents to the clinic.  

A typical day for this candidate would include these responsibilities:

  • Research, design and/or execution of in vitro/ex vivo assays that:
    • Inform on compound mechanism of action and drug resistance
    • Enable the identification of markers for patient selection and drug target engagement
    • Interrogate combinatorial activity with other therapeutics
    • Aid in supporting in vivo dosing schedule
    • Identify/support the use of species for toxicity studies

These assays include Western blotting, ELISA, bead-based immunoassays, qRT-PCR, flow cytometry and IHC from human and animal primary and cancer cell lines, blood and tissues. 


  • Assisting in the design of, and analysis of tissues from, in vivo studies to support your hypotheses including PK, PD, and tumor efficacy studies
  • Critically analyzing and interpreting data; suggesting studies to validate/follow up
  • Documenting studies in an electronic notebook
  • Compiling results in an organized format and clearly presenting to manager, project team, and company meetings
  • Reading literature to expand your understanding of current drug target(s) to identify/support disease areas and predictive/response biomarkers
  • Contributing to authorship of clinical trial related documents and scientific manuscripts (when required)


  • Senior Research Associate: BS in a scientific discipline with a minimum of 5-7 years of oncology translational research experience with BS or 5-8 years with MS  OR
  • Research Scientist I: BS in a scientific discipline with a minimum of 7 years of oncology translational research experience, MS with 5 years of relevant experience, or PhD/Postdoc with relevant experience
  • Significant knowledge of cancer biology and experience in small molecule cancer drug development
  • Expertise in mammalian cell culture and cell/tissue-based techniques (engineering cell lines, developing plate based assays)
  • Technical experience with different protein expression/modification testing platforms including ELISA, Western blot, bead-based immunoassays, flow cytometry, IHC, microscopy
  • Experience in NGS (RNAseq, ChIPseq) and bioinformatics is helpful but not required
  • Capable of independently conducting innovative research, works well in a team environment and proactively shares data/learnings to increase awareness and quickly overcome challenges
  • Ability to analyze, interpret and present data in a clear fashion is essential
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