Research Scientist, Biochemistry, Biophysics, & Crystallography
C4 Therapeutics Inc Watertown, MA

We are seeking an enthusiastic, scientifically motivated research scientist to join our Biochemistry, Biophysics & Crystallography team. The candidate will play a significant role in the structure-guided design of hetero-bifunctional degraders to advance early drug discovery projects and in doing so will be participating in laying the design foundations for an emerging new drug modality with the potential to address yet to be drugged targets.  The ideal candidate will possess a strong background in the fields of structural biology or biophysics and a foundation in small molecule drug discovery.  In addition, the successful candidate will have a strong commitment to team success, ability to work effectively within multidisciplinary project teams, and the ability to handle multiple projects simultaneously. This position seeks individuals who are comfortable with a fast-paced environment and combine innovative/diverse approaches with strong foundational understandings in chemistry to help advance drug discovery projects.  C4 Therapeutics is committed to investing in you by providing strong leadership, defined career growth opportunities, exposure to state-of-the-art techniques, and a highly positive work environment with top talent. 



  • Provide in-depth structure-guided expertise to ongoing and future drug discovery programs to help advance early drug discovery chemistry campaigns.
  • Design and execute protein crystallization experiments and elucidate the binding mode of ligands to targets of relevance
  • Work with multidisciplinary groups (pharmacology, translational biology, computational chemistry & medicinal chemistry) to initiate and advance drug discovery programs.


  • PhD in Structural Biology, Biophysics or another relevant discipline with 1-5 years’ experience or equivalent in a research laboratory in an academic and/or industry setting
  • Well versed in all aspects of X-ray crystallography from crystal generation to structure solution.  Experience in protein construct design, expression, and purification preferred.
  • Understanding of modeling and docking favorably considered.
  • Aptitude with detailed structural analyses and integration of structural observations with biochemical and biophysical data.
  • Familiarity with in vitro biochemical methods such as SPR/Biacore, FP, FRET, ITC and their application to structure-activity relationships
  • Ability to works well in a collaborative team-oriented environment and capable of independently conducting innovative research.
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