Senior Research Scientist
C4 Therapeutics Inc Watertown, MA

About C4 Therapeutics

C4 Therapeutics is pioneering a new class of drugs. C4’s technology platform produces small molecule drugs that harness machinery already present in cells to selectively target disease-relevant proteins for degradation. Our approach has the potential to address a broad range of diseases including cancer, infectious disease, and autoimmune disorders.



-       Develop and execute synthetic routes of target molecules, including work up, purification, isolation, and characterization of products.

-       Optimize drug candidates through interpretation of complex data sets through iterative SAR.

-       Utilize computational approaches, including structure guided drug design, to optimize chemical leads.

-       Work with a multidisciplinary groups to initiate and advance drug discovery programs.

-       Manage external study execution at contract research organizations and engage with extramural industry and academic collaborators.

-       Contribute to the writing of patents, scientific presentations, and publications.

-       Critically analyze data and communicate findings effectively to multidisciplinary team members and senior management.



 PhD in organic chemistry with 4+ years of relevant biopharma/pharma experience or BS/MS in organic or medicinal chemistry with a minimum of 10 years of relevant experience, preferably in the biopharma/pharma setting.

-       Proven scientific track record of advancing small molecules through stage gate milestones from Hit ID through candidate selection.

-       Expertise in synthetic organic chemistry, including methodologies, transformations, and mechanisms.

-       Ability to work independently and apply experience and knowledge to solve difficult synthetic challenges and provide useful guidance to other chemists on the project team.

-       Strong motivation, independence, and ability to work in a high-pace multidisciplinary, matrix environment with minimal supervision.

-       Demonstrated ability to effectively manage and mentor research staff.

-       Excellent interpersonal as well as oral and written communication skills required.

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