DMPK Scientist
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C4 Therapeutics, Inc. is seeking a highly motivated DMPK Scientist to contribute to the discovery and development of small molecule therapeutics that enable the UPS-mediated degradation of proteins implicated in disease. Reporting to the Senior Director of DMPK, the ideal DMPK candidate will be responsible for internal and external DMPK data generation, problem-solving, and ongoing nimble integration of DMPK discipline into C4T’s advancing portfolio.  

Objectives:

  • Broad understanding of DMPK function in drug discovery and development
  • Support C4T drug discovery projects ranging from lead optimization to candidate selection through generation, analysis and interpretation of internally and externally generated ADME data
  • Design and execution of in vitro and in-vivo ADME studies to enable rapid advancement of compounds through discovery and preclinical development

Accountabilities:

  • Identify/Develop appropriate assays to assess drug-like properties of new chemical entities
  • Provide DMPK support and guidance to project teams
  • Design and execute program-specific ADME studies on an as-needed basis

Qualifications

EDUCATION, COMPETENCIES, AND SKILLS:

A Ph.D. in pharmaceutical or related discipline with ≥ 2-year industry experience or an MS in pharmaceutical sciences, analytical chemistry or related disciplines with ≥ 5 years of industry experience in a DMPK setting

  • Strong and deep knowledge of in-vitro and in-vivo ADME of small molecules
  • Experience with PK/PD Modeling as applied to small molecules
  • Hands-on experience in CYP inhibition/induction and/or Transporter assays highly desirable
  • Self-starter and independent thinker
  • Ability to multi-task and work in a fast-paced environment
  • Excellent communication and writing skills
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