QSP Modeler / DMPK Project Team Representative
C4 Therapeutics Inc Watertown, MA
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About C4 Therapeutics

C4 Therapeutics is pioneering a new class of drugs. C4’s technology platform produces small molecule drugs that harness machinery already present in cells to selectively target disease-relevant proteins for degradation. Our approach has the potential to address a broad range of diseases including cancer, infectious disease, and autoimmune disorders.

 

C4 Therapeutics is seeking a highly motivated Quantitative Systems Pharmacology Modeler/ DMPK Project Team Representative to contribute to the discovery and development of small molecule therapeutics that enable the UPS-mediated degradation of proteins implicated in disease. Reporting to the Director of DMPK, the ideal candidate will be responsible for developing QSP/PBPK models for C4T’s pipeline, representing DMPK function on project teams, problem solving, and ongoing nimble integration of the discipline into C4T’s advancing portfolio.

 

Objectives:

  • In this role, the individual  will work with integrated project teams to co-develop medicinal chemistry strategy and DMPK screening strategy to address in vivo performance issues, through analysis based on QSP/PBPK based models, in vitro ADME and PK.
  • Selecting and balancing internal data production with external CRO capabilities to ensure high quality and on-time execution of ADME studies.

 

Accountabilities:

  • Responsible for bridging the in-vitro cell pharmacology data and in-vivo PK/PD observations to develop robust and predictive QSP/PBPK models
  •  Design, management, analysis and interpretation of ADME, PK and PK/PD studies
  • The candidate will be required to analyze and present data and trends, both orally and as written reports.

 

Preferred Qualifications:

  • A Ph.D. in pharmaceutical or related discipline with ≥ 3 year industry experience or a BS/MS in pharmaceutical sciences, analytical chemistry or related disciplines with ≥ 7 years of industry experience in a DMPK/Pharmacometrics setting.
  • Demonstrable expertise and experience in developing QSP models
  • Extensive knowledge of in-vitro/in-vivo ADME properties for small molecules.
  • Experience working as DMPK representative on drug discovery programs is desirable
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