We are seeking an enthusiastic, scientifically motivated in vivo pharmacologist to be a key member of our team developing a new class of targeted protein degradation therapeutics. In this role, you will apply your in vivo pharmacology expertise and leadership capabilities to support multiple oncology programs.
- Immediately as In Vivo Pharmacology Lead, you will help develop the in vivo strategy alone or in partnership with a senior scientist depending on your experience level. You will communicate plans and timelines across functions, and oversee the execution of studies (including tolerability, PD, efficacy) through an external CRO. Thus, this role will not require hands-on animal work though there is the option of performing infrequent studies at a local in vivo facility.
- Identify optimal disease models through CROs or academic collaborations
- Proactively recognize and solve technical and scientific issues to assure high-quality data from external resources
- Critically analyze in vivo data to develop in vitro – in vivo correlations and PK/PD/efficacy relationships to understand the pharmacology of compounds
- Perform target engagement studies from cell culture and animal tissues including immunoassays, PCR and other bioassays
- Maintain awareness of relevant literature to aid in identifying predictive and target engagement biomarkers, emerging indications and mechanisms of drug resistance
- Work effectively with other disciplines to build a preclinical data package for candidate nomination and clinical development, contributing authorship to clinical trial related documents and scientific manuscripts
- BS/MS degree in Pharmacology or Biology with 5+ years of relevant experience or Ph.D. with 2+ years of relevant experience in a research laboratory from an academic and/or industry setting
- Demonstrated success as an in vivo pharmacologist, with a proven track record of good experimental design, in-depth data analysis, and interpretation based on strong scientific rationale
- Excellent project management skills and the ability to effectively manage CROs
- Good understanding of ADME & DMPK results and interpretation to inform on in vivo study strategy/needs
- Experienced in cell culture and analytical techniques such as ELISA, Western blot, PCR, flow cytometry
- Demonstrated ability to organize, analyze, and communicate complex data sets