Structural Biology - 2019 Summer Internship
C4 Therapeutics Inc Watertown, MA



  • Approximately 3-5 college interns for summer 2019
  • Begin in June and last approximately 10 weeks, depending on semester/trimester timing
  • Interns will work on a specific project(s) throughout the summer
  • Interns will give a 20-min presentation in mid-August
  • HR will coordinate bi-weekly brown bag lunch events with speakers from different teams/areas
  • HR will hold an interview, resume, and phone screen training
  • We will host several social activities



Some Structural Biology and Protein Science projects will include: 

Modification and optimization of internal insect cell expression technologies

  • Training in molecular cloning and expression vector modification
  • Insect cell culture and baculovirus production/characterization
  • Protein expression and purification from insect cells


Establishing structural biology systems for targets involved in neurological diseases

  • Training in basic molecular biology techniques
  • Bacterial protein expression and purification
  • Biophysical characterization of purified proteins
  • Protein crystallization and optimization


Crystallography and assessment of degrader-induced protein complexes

  • Training in protein purification
  • Biophysical characterization of protein complexes
  • In vitro assay development
  • High throughput protein crystallization using robotic systems


Establishing a high throughput protein expression platform for E3 ubiquitin ligases

  • Training in high throughput cloning techniques
  • Low volume, high capacity bacterial protein expression and purification
  • Tissue culture experience working with insect cell protein expression systems



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