Research Associate - Cell Pharmacology
C4 Therapeutics Inc Watertown, MA
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We are seeking an enthusiastic, scientifically motivated research associate to join the Cell Pharmacology team. The candidate will play a significant role in the development and implementation of in vitro cellular assays to identify and evaluate our degraders to advance early drug discovery projects. The ideal candidate will possess a strong background in the fields of molecular and cellular biology and biochemistry. In addition, the successful candidate will have a strong commitment to team success, ability to work effectively within multidisciplinary project teams, and the ability to work on multiple projects simultaneously. This position seeks individuals who are comfortable with a fast-paced environment and combine innovative/diverse approaches to assay development including lentiviral and CRISPR technologies. While a lot will be expected of this candidate, C4 Therapeutics is committed to investing in the right candidate by providing strong leadership, career growth opportunities, exposure to state of the art techniques, and a highly positive workplace environment with top talent. 

Responsibilities:

  • Perform tissue culture (maintaining a number of cell lines/cell types)
    • Lentiviral production and transduction for stable cell line generation
    • CRISPR generated knockout/knock-in cell lines
      • Staying up to date with emerging technologies to improve efficiencies
      • Provide expertise in this area to other colleagues to support internal/external programs
      • Design, optimize and execute a number of cellular assays (CTGlo viability, HiBiT, HTRF, NanoBRET)
      • Data analysis and interpretation to drive chemistry SAR to support drug discovery programs
        • Data sharing and communication to project teams
        • Work with project team leads or members from other functional areas to discuss data, next steps, and plan experiments to address key questions
        • Maintain laboratory records (ELN)

Qualifications

  • BS/MS with lab experience in biology, biochemistry, or other related disciplines
  • Experience with aseptic technique and mammalian cell culture preferred
  • Experience with Echo or acoustic liquid dispenser, Envision, Combi, WES, LI-COR, Neon/Amaxa electroporator, single cell sorter a plus
  • Self-motivated, willingness to learn, and strong work ethic
  • Attention to details, organizational skills, and excellent communication skills
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