Research Scientist I - Proteomics & UPS Biology
C4 Therapeutics Inc Watertown, MA
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C4 Therapeutics is looking for a highly motivated and detail-oriented Research Scientist 1 level individual for the Proteomics and Ubiquitin-Proteasome System (UPS) Biology group. This person is expected to work independently to perform cell-based and tissue-based proteomics experiments involving the effects of small molecule treatment. This person should have a solid understanding of, and experience with, tissue culture techniques and is also expected to have established skills in processing cell line derived samples including generation of cell extracts for affinity purification, SDS-PAGE, Western Blotting (or equivalent). Experience with sample processing for proteomic application is a plus, but not required as these skills will be taught in alignment with company SOPs. It is further expected that this individual possesses strong organizational skills, the ability to design, execute, troubleshoot, and analyze experimental biological data, and a proven ability to handle multiple efforts at the same time while delivering the highest quality results.

Responsibilities.

  • Routine tissue culture of relevant cell lines
  • Design and execution of biological experiments with clearly defined goals and objectives
  • Perform Mass Spec-based experiments, including sample preparation and data processing
  • Work with team members within and across functional areas to achieve key company goals
  • Analyze, summarize, and present data at team meetings and broader project team meetings

Qualifications.

  • BS (8+ years of industry experience) or Ph.D. with lab experience in biology, biochemistry, or other related disciplines
  • Experience with mammalian cell culture, cellular assays, and data analysis software tools
  • Experience with proteomic assays and data analysis is a plus, but not required
  • Experience in supporting the discovery and early development of small molecule therapeutics is a plus
  • Self-motivated, willingness to learn, and strong work ethics with attention to detail, strong organization skills, and excellent communication skills
  • Sense of humor and ability to work in a fast-paced environment
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